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Terpene Tuesday: Caryophyllene

Terpene Tuesday: Caryophyllene

Posted by Susan Lyn Kupiec, RN on 8th Jun 2021

TERPENE: Caryophyllene / kærioʊˈfɪliːn / bicyclic

The body has 2 major endocannabinoid receptors:

  • CB1 (receptors are primarily in the brain and central nervous system) and
  • CB2 (receptors found mostly in the peripheral organs)

When the cannabinoid THC is ingested, it primarily binds to CB1 receptors, which causes the euphoric effect.

Caryophyllene is a bigger molecule than any other terpene and has a unique cyclobutane ring, which is rarely found in nature and not found in any other terpene.

Caryophyllene is the only terpene known to activate the endocannabinoid receptors in the brain. Due to caryophyllene’s unique molecular structure it also binds with CB2 receptors and may aid in reducing inflammation in the body.

FOUND IN: Cloves, pepper, black caraway, cannabis, hops, basil, oregano, lavender, rosemary, cinnamon, and ylang-ylang.

AROMA/FLAVOR: peppery, spicy, woodsy, floral earthy


  • Ease aches and pains
  • Decreases inflammation
  • Reduces stress


  • Anti-inflammatory
  • Antioxidant
  • Research showing to help treat bowel disease
  • Early research show binding with CB2 receptor to aid in treating of alcohol dependency

Supportive for:

  • Atherosclerosis
  • Osteoporosis.
  • Chronic Pain


  • GSC - full body relaxation (Hybrid)
  • Bubba Kush - head to toes relaxation effect while reducing stress and increasing euphoria (Indica)
  • Sour Diesel - fasting acting cerebral high, energizing (Sativa)
  • Chem Dog - use caution, heavy body and cerebral effect (Hybrid)


Proceedings Of The National Academy Of Sciences

Farmacy Santa Barbara

National Library Of Medicine


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